There are many myths about the human sense of smell. Most persistent are the views that our olfactory abilities are underdeveloped, declining, and lacking cognitive significance. Nothing could be further from the truth. Historically, the spice trade and the ongoing hunt for new flavors have shaped our modern socio-economic landscape. Today, 28 billion dollars are generated annually with fragrance products in the US alone (ranging from perfumes to scented trash bags). Many of these are deeply entwined with hygiene products responsible for improvements in public health. And over the past thirty years, neuroscientific interest in odor perception has been on a steady rise. Central to this development is the dominant role of smell in cross-modal processes of flavor perception. The crucial question here remains unresolved, however: How does our brain make sense of scents and flavors? To explore the human sense of smell in its perceptual, neural, and cultural dimensions, the panel brings together cross-disciplinary perspectives from neuroscience, philosophy, and perfumery.